pubmed http://www.ncbi.nlm.nih.gov/pubmed NEJM http://www.nejm.org/ Lancet http://www.thelancet.com/ JCO http://jco.ascopubs.org/ Blood http://www.bloodjournal.org/ Lancet Oncology http://www.thelancet.com/journals/lanonc/issue/current Lan…
Personalized Prediction Model to Risk Stratify Patients With Myelodysplastic SyndromesJ Clin Oncol. 2021 Aug 18;JCO2002810.PMID: 34406850 DOI: 10.1200/JCO.20.02810 目的骨髄異形成症候群(MDS)患者の生命予後は、数ヶ月から数十年までの幅がある。…
Evaluation of Sustained Minimal Residual Disease Negativity With Daratumumab-Combination Regimens in Relapsed and/or Refractory Multiple Myeloma: Analysis of POLLUX and CASTORJ Clin Oncol. 2021 Apr 1;39(10):1139-1149. doi: 10.1200/JCO.20.0…
Carfilzomib or bortezomib in combination with lenalidomide and dexamethasone for patients with newly diagnosed multiple myeloma without intention for immediate autologous stem-cell transplantation (ENDURANCE): a multicentre, open-label, ph…
Simplified Geriatric Assessment in Older Patients With Diffuse Large B-Cell Lymphoma: The Prospective Elderly Project of the Fondazione Italiana LinfomiJ Clin Oncol. 2021 Apr 10;39(11):1214-1222. doi: 10.1200/JCO.20.02465. Epub 2021 Feb 12…
Successful tyrosine kinase inhibitor discontinuation outside clinical trials - data from the population-based Swedish chronic myeloid leukaemia registryBr J Haematol. 2021 Mar 30. doi: 10.1111/bjh.17392.PMID: 33782950 DOI: 10.1111/bjh.1739…
Maternal and neonatal outcomes in 80 patients diagnosed with non-Hodgkin lymphoma during pregnancy: results from the International Network of Cancer, Infertility and PregnancyBr J Haematol. 2021 Apr;193(1):52-62. doi: 10.1111/bjh.17103. Ep…
Burkitt Lymphoma International Prognostic IndexJ Clin Oncol. 2021 Apr 1;39(10):1129-1138. doi: 10.1200/JCO.20.03288.PMID: 33502927 DOI: 10.1200/JCO.20.03288 目的バーキットリンパ腫 Burkitt lymphoma (BL)は特有の生物学的性質と臨床経過を持つが…
Rituximab plus high-dose chemotherapy (MegaCHOEP) or conventional chemotherapy (CHOEP-14) in young, high-risk patients with aggressive B-cell lymphoma: 10-year follow-up of a randomised, open-label, phase 3 trialClinical Trial Lancet Haema…
PET-guided omission of radiotherapy in early-stage unfavourable Hodgkin lymphoma (GHSG HD17): a multicentre, open-label, randomised, phase 3 trialLancet Oncol. 2021 Feb;22(2):223-234. doi: 10.1016/S1470-2045(20)30601-X.PMID: 33539742 DOI: …
Prognostic Value of Interim FDG-PET in Diffuse Large Cell Lymphoma: Results From the CALGB 50303 Clinical TrialPMID: 32232481 DOI: 10.1182/blood.2019003277 大細胞リンパ腫のランダム化・前向き臨床試験の一部として、著者らはベースライン、化学…
Subcutaneous delivery of daratumumab in relapsed or refractory multiple myeloma.Blood. 2019 Aug 22;134(8):668-677. doi: 10.1182/blood.2019000667.PMID: 31270103 ダラツムマブはCD38を標的としたヒトモノクローナル抗体であり、多発性骨髄腫(MM)患…
Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease.N Engl J Med. 2020 May 7;382(19):1800-1810. doi: 10.1056/NEJMoa1917635.PMID: 32320566 背景急性GVHDは依然として同種幹細胞移植の主要な制約の一つである。全ての患者が標…
Nonmyeloablative Alternative Donor Transplantation for Hodgkin and Non-Hodgkin Lymphoma: From the LWP-EBMT, Eurocord, and CIBMTR.J Clin Oncol. 2020 May 10;38(14):1518-1526. doi: 10.1200/JCO.19.02408.PMID: 32031876 目的ホジキンリンパ腫と非…
レムデシビルの国際多施設共同第3相試験の中間解析結果です。 NIH Clinical Trial Shows Remdesivir Accelerates Recovery from Advanced COVID-19(https://www.niaid.nih.gov/news-events/nih-clinical-trial-shows-remdesivir-accelerates-recovery-advanc…
Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trialLancet 2020, DOI:https://doi.org/10.1016/S0140-6736(20)31022-9 背景 重症の新型コロナウイルス感染症(COVID-19)患者の治療において効果…
Early progression after bendamustine-rituximab is associated with high risk of transformation in advanced stage follicular lymphoma.Blood. 2019 Aug 29;134(9):761-764. doi: 10.1182/blood.2019000258. Epub 2019 Jul 12.PMID: 31300404 進行期の…
Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma.N Engl J Med. 2019 Aug 22;381(8):727-738. doi: 10.1056/NEJMoa1903455.PMID: 31433920 背景核外搬出化合物の選択的阻害薬であるselinexorは、exportin 1 (XPO1)をブロックし…
CD19 CAR T cells following autologous transplantation in poor-risk relapsed and refractory B-cell non-Hodgkin lymphoma.Blood. 2019 Aug 15;134(7):626-635. doi: 10.1182/blood.2018883421. Epub 2019 Jul 1.PMID: 31262783 PMCID: PMC6695562 大量…
Short regimen of rituximab plus lenalidomide in follicular lymphoma patients in need of first-line therapy.Blood. 2019 May 17. pii: blood-2018-10-879643. doi: 10.1182/blood-2018-10-879643.PMID: 31101627 SAKK 35/10はSwiss Group for Clinical…
Early progression after BR is associated with high risk of transformation in advanced stage follicular lymphoma.Blood. 2019 Jul 12. pii: blood.2019000258.PMID: 31300404 DOI: 10.1182/blood.2019000258 進行期の濾胞性リンパ腫 follicular lympho…
Positron Emission Tomography Score Has Greater Prognostic Significance Than Pretreatment Risk Stratification in Early-Stage Hodgkin Lymphoma in the UK RAPID Study.J Clin Oncol. 2019 Jul 10;37(20):1732-1741.PMID: 31112475 DOI: 10.1200/JCO.1…
Dose-Adjusted EPOCH-R Compared With R-CHOP as Frontline Therapy for Diffuse Large B-Cell Lymphoma: Clinical Outcomes of the Phase III Intergroup Trial Alliance/CALGB 50303.J Clin Oncol. 2019 Jul 20;37(21):1790-1799.PMID: 30939090 DOI: 10.1…
Stand-alone intrathecal central nervous system (CNS) prophylaxis provide unclear benefit in reducing CNS relapse risk in elderly DLBCL patients treated with R-CHOP and is associated increased infection-related toxicity.Br J Haematol. 2019 …
Role of urine immunofixation in the complete response assessment of MM patients other than light-chain-only disease.Blood. 2019 Jun 20;133(25):2664-2668.PMID: 31010846 doi: 10.1182/blood.2019000671. 多発性骨髄腫(MM)の治療効果判定クライテリ…
Final Results of a Randomized, Phase III Study of Rituximab With or Without Idelalisib Followed by Open-Label Idelalisib in Patients With Relapsed Chronic Lymphocytic Leukemia.J Clin Oncol. 2019 Jun 1;37(16):1391-1402PMID: 30995176 doi: 10…
First-Line Treatment of Patients With Indolent Non-Hodgkin Lymphoma or Mantle-Cell Lymphoma With Bendamustine Plus Rituximab Versus R-CHOP or R-CVP: Results of the BRIGHT 5-Year Follow-Up Study. J Clin Oncol. 2019 Apr 20;37(12):984-991. do…
Randomized trial of ibrutinib vs ibrutinib plus rituximab in patients with chronic lymphocytic leukemia. Blood. 2019 Mar 7;133(10):1011-1019 PMID: 30530801, DOI: 10.1182/blood-2018-10-879429 イブルチニブは,経口のブルトン型チロシンキナーゼ…
Cryotherapy as prophylaxis against oral mucositis after high-dose melphalan and autologous stem cell transplantation for myeloma: a randomised, open-label, phase 3, non-inferiority trial. Bone Marrow Transplant. 2019 Feb 4 PMID: 30718802 D…
最近は中枢神経リンパ腫の論文を目にする機会が多い気がします。 尚,この論文で用いられているCNS-IPIについては,過去記事も参考にしてください。 kusarenaikai.hatenablog.com Integration of cell of origin into the clinical CNS International Progno…