Autologous Transplantation, Consolidation, and Maintenance Therapy in Multiple Myeloma: Results of the BMT CTN 0702 Trial. J Clin Oncol. 2019 Mar 1;37(7):589-597 PMID: 30653422, DOI: 10.1200/JCO.18.00685 目的 メルファラン 200 mg/m2の投与と…
Long‐term overall‐ and progression‐free survival after pentostatin, cyclophosphamide and rituximab therapy for indolent non‐Hodgkin lymphoma https://doi.org/10.1111/bjh.15814 治療歴のない進行期のindolent非ホジキンリンパ腫(iNHL)患者を対象と…
Randomized phase 3 study of carfilzomib or bortezomib with melphalan-prednisone for transplant-ineligible, NDMM patients doi: 10.1182/blood-2018-09-874396 第3相試験であるCLARION試験は，移植非適応の未治療多発性骨髄腫患者を対象とし，カルフィ…
Eltrombopag treatment during induction chemotherapy for acute myeloid leukaemia: a randomised, double-blind, phase 2 study. Lancet Haematol. 2019 Jan 28 PMID: 30704923, DOI: 10.1016/S2352-3026(18)30231-X 背景 急性骨髄性白血病患者は，寛解導…
Allogeneic transplantation of multiple myeloma patients may allow long-term survival in carefully selected patients with acceptable toxicity and preserved quality of life. PMID: 30237266, PMCID: PMC6355495, DOI: 10.3324/haematol.2018.200881…
Virus detection in the cerebrospinal fluid of hematopoietic stem cell transplant recipients is associated with poor patient outcomes: a CIBMTR contemporary longitudinal study. PMID: 30696997 DOI: 10.1038/s41409-019-0457-9 同種造血幹細胞移…
Viral, immunologic, and clinical features of primary effusion lymphoma. PMID: 30782610, DOI: 10.1182/blood-2019-01-893339 原発性体腔液リンパ腫(primary effusion lymphoma, PEL)はHIVに関連したアグレッシブリンパ腫であり，効果的なHIV治療が可能…
Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial.Lancet. 2019 Jan 19;393(10168):229-240PMID: 30522922, doi: 10.1016/S0140-6736(18)32984-2 背景…
Guidelines for the diagnosis and management of primary central nervous system diffuse large B-cell lymphoma Br J Haematol. 2019 Feb;184(3):348-363. PMID: 30467845, doi: 10.1111/bjh.15661. 中枢神経原発リンパ腫(primary CNS lymphoma, PCNSL)の…
Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura. N Engl J Med. 2019 Jan 24;380(4):335-346. PMID: 30625070, DOI: 10.1056/NEJMoa1806311 背景 後天性の血栓性血小板減少性紫斑病(TTP)は，von Willebrand因子を切断するプロテ…
Ibrutinib Regimens versus Chemoimmunotherapy in Older Patients with Untreated CLL. (N Engl J Med. 2018 Dec 27;379(26):2517-2528.) PMID: 30501481, PMCID: PMC6325637 [Available on 2019-06-27] DOI: 10.1056/NEJMoa1812836 背景 イブルチニブは201…
Dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) in untreated aggressive diffuse large B-cell lymphoma with MYC rearrangement: a prospective, multicentre, single-arm phase 2 study. (L…
Elotuzumab plus Pomalidomide and Dexamethasone for Multiple Myeloma. N Engl J Med. 2018 Nov 8;379(19):1811-1822 PMID: 30403938, doi: 10.1056/NEJMoa1805762. 背景 免疫賦活性モノクローナル抗体であるエロツズマブにレナリドミドとデキサメタゾンを…
Reduced-intensity conditioning versus standard conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid leukaemia in first complete remission: a prospective, open-label randomised phase 3 trial. Lance…
Long-term efficacy of reduced-intensity versus myeloablative conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid leukaemia in first complete remission: retrospective follow-up of an open-label, r…
Rituximab plus Lenalidomide in Advanced Untreated Follicular Lymphoma. N Engl J Med. 2018 Sep 6;379(10):934-947. 背景 リツキシマブと化学療法の併用は，治療歴が無い進行期の濾胞性リンパ腫に有効であることが示されている。それにもかかわらず，ほ…
Intravenous immunoglobulin vs observation in childhood immune thrombocytopenia: a randomized controlled trial (Blood. 2018;132:883-891) PMID: 29945954, doi: 10.1182/blood-2018-02-830844 免疫性血小板減少症immune thrombocytopenia (ITP)と診断…
Rituximab and the risk of transformation of follicular lymphoma: a retrospective pooled analysis. (Lancet Haematol. 2018 Aug;5(8):e359-e367.) PMID: 30078408 DOI: 10.1016/S2352-3026(18)30090-5 背景 濾胞性リンパ腫からアグレッシブリンパ腫への…
Positron Emission Tomography–Guided Therapy of Aggressive Non-Hodgkin Lymphomas (PETAL): A Multicenter, Randomized Phase III Trial PMID: 29750632, DOI: 10.1200/JCO.2017.76.8093 目的 [18F]fluorodeoxyglucoseをトレーサーに用いたinterim positr…
Daratumumab plus pomalidomide and dexamethasone in relapsed and/or refractory multiple myeloma.Blood. 2017 Aug 24;130(8):974-981. www.ncbi.nlm.nih.gov 2種類以上の前治療歴があり、直近の治療が効かなかった再発・難治性の多発性骨髄腫の患者を対…
Pomalidomide Plus Low-Dose Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma and Renal Impairment: Results From a Phase II Trial J Clin Oncol 2018 www.ncbi.nlm.nih.gov 目的腎障害(renal impairment; RI)は再発・難治性骨髄腫(…
ダラツムマブdaratumumab(ダラザレックス®)は、日本では2017年9月に承認されたばかりの新薬で、今のところ再発・難治性の多発性骨髄腫に適応があります。 Daratumumab plus Bortezomib, Melphalan, and Prednisone for Untreated MyelomaN Engl J Med 2018;3…
Acalabrutinib in relapsed or refractory mantle cell lymphoma (ACE-LY-004): a single-arm, multicentre, phase 2 trial Lancet 2017 背景ブルトン型チロシンキナーゼはマントル細胞リンパ腫の臨床的に妥当な治療ターゲットである。acalabrutinib (ACP-19…
Selective Inhibition of Nuclear Export With Oral Selinexor for Treatment of Relapsed or Refractory Multiple Myeloma. J Clin Oncol 2018, doi: 10.1200/JCO.2017.75.5207. 目的selinexorは画期的な新薬で、exportin 1 (XPO1)を選択的に阻害し、腫瘍蛋…
Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma.N Engl J Med. 2017;377:2531-2544. 背景第1相試験において、自家抗CD19キメラ抗原受容体T細胞療法であるaxicabtagene ciloleucel (axi-cel)は従来の治療が効かない治療抵…
Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin’s Lymphoma N Engl J Med 2018;378:331-344 背景ブレンツキシマブ・ベドチンは抗CD30抗体と薬剤の結合物であり、再発または難治性のホジキンリンパ腫に適応がある。 方法著者らは、オー…
Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia N Engl J Med 2018;378:449-459 背景再発したB細胞性の急性リンパ性白血病(B-ALL)患者において、CD19特異的キメラ抗原受容体(CAR)T細胞は高い奏効率を示し、一部のグループでは長…
Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia. N Engl J Med. 2018;378:439-448. 背景 単施設の第1-2a相試験において、抗CD19キメラ抗原受容体(CAR)発現T細胞 tisagenlecleucelによる治療は、小児と若年成人の再発・…
Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma: a retrospective study from the EBMT Lymphoma Working Party www.ncbi.nlm.nih.gov マントル細胞リンパ腫(MCL)患者におい…
Rituximab maintenance versus observation following abbreviated induction with chemoimmunotherapy in elderly patients with previously untreated chronic lymphocytic leukaemia (CLL 2007 SA): an open-label, randomised phase 3 studyLancet Haema…
