自家造血幹細胞移植
Rituximab plus high-dose chemotherapy (MegaCHOEP) or conventional chemotherapy (CHOEP-14) in young, high-risk patients with aggressive B-cell lymphoma: 10-year follow-up of a randomised, open-label, phase 3 trialClinical Trial Lancet Haema…
CD19 CAR T cells following autologous transplantation in poor-risk relapsed and refractory B-cell non-Hodgkin lymphoma.Blood. 2019 Aug 15;134(7):626-635. doi: 10.1182/blood.2018883421. Epub 2019 Jul 1.PMID: 31262783 PMCID: PMC6695562 大量…
Cryotherapy as prophylaxis against oral mucositis after high-dose melphalan and autologous stem cell transplantation for myeloma: a randomised, open-label, phase 3, non-inferiority trial. Bone Marrow Transplant. 2019 Feb 4 PMID: 30718802 D…
Autologous Transplantation, Consolidation, and Maintenance Therapy in Multiple Myeloma: Results of the BMT CTN 0702 Trial. J Clin Oncol. 2019 Mar 1;37(7):589-597 PMID: 30653422, DOI: 10.1200/JCO.18.00685 目的 メルファラン 200 mg/m2の投与と…
Whole-brain radiotherapy or autologous stem-cell transplantation as consolidation strategies after high-dose methotrexate-based chemoimmunotherapy in patients with primary CNS lymphoma: results of the second randomisation of the Internatio…
Autotransplant with and without induction chemotherapy in older multiple myeloma patients: long-term outcome of a randomized trial. Haematologica. 2016;101:1398-1406. www.ncbi.nlm.nih.gov 高齢の多発性骨髄腫に対する自家移植は議論の余地があ…
High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial. Lancet Haematol. 2016;3:e388-397 www.ncbi.nlm.nih.gov 背景 大量メトトレキサー…
A Comprehensive Assessment of Toxicities in Patients with CNS Lymphoma Undergoing Autologous Stem Cell Transplantation Using Thiotepa, Busulfan and Cyclophosphamide Conditioning. Biol Blood Marrow Transplant. 2016, PMID 27713090 www.ncbi.n…
Upfront use of plerixafor and granulocyte-colony stimulating factor (GCSF) for stem cell mobilization in patients with multiple myeloma: efficacy and analysis of risk factors associated with poor stem cell collection efficiency. Leuk Lymph…
Randomized Comparison of Gemcitabine, Dexamethasone, and Cisplatin Versus Dexamethasone, Cytarabine, and Cisplatin Chemotherapy Before Autologous Stem-Cell Transplantation for Relapsed and Refractory Aggressive Lymphomas (JCO 2014;32:3490-…
High-dose chemotherapy plus autologous stem-cell transplantation as consolidation therapy in patients with relapsed multiple myeloma after previous autologous stem-cell transplantation (NCRI Myeloma X Relapse [Intensive trial]): a randomis…
Complete response after autologous stem cell transplant in multiple myeloma. (Cancer Med 2014, PMID 24777883) 著者らは自家幹細胞移植(ASCT)後に完全奏功(CR)を達成した骨髄腫患者の長期予後を評価した。1990年4月から2012年6月までの間に191例がASCT…
Long-term clinical and molecular remissions in patients with mantle cell lymphoma following high-dose therapy and autologous stem cell transplantation.(Ann Hematol 2014;93:803-810)自家幹細胞移植を併用した大量化学療法(HDT-ASCT)の後に臨床的…
Phase I/II study of bortezomib-BEAM and autologous hematopoietic stem cell transplantation for relapsed indolent non-Hodgkin lymphoma, transformed, or mantle cell lymphoma.(Biol Blood Marrow Transplant 2014;20:536-542)標準的BEAMと自家造血…
Autologous stem cell transplantation in mantle cell lymphoma: a report from the SFGM-TC.(Ann Hematol 2014;93:233-242)自家幹細胞移植は若年のマントル細胞リンパ腫(MCL)患者にとって魅力的な治療選択肢の一つと考えられている。本研究はSFGM-TC study…
Nordic MCL-3 study: BEAM/C conditioning intensified with 90Y-Ibritumomab-Tiuxetan in responding non-CR patients followed by autologous transplant in mantle cell lymphoma.(Blood 2014;123:2953-2959)本研究の主な目的は、移植前にCRを達成出来な…
False-Positive [18F]Fluorodeoxyglucose-Avid Lymph Nodes on Positron Emission Tomography-Computed Tomography After Allogenic but Not Autologous Stem-Cell Transplantation in Patients With Lymphoma (JCO 2013, PMID 24248697) [目的] 造血幹細胞…
Treatment of high-risk aggressive B-cell non-Hodgkin lymphomas with rituximab, intensive induction and high-dose consolidation: the long-term analysis of the R-MegaCHOP-ESHAP-BEAM Trial.(Leuk Lymphoma 2014, PMID 24628294)著者らは本試験にお…
R-CHOP/R-DHAP Compared to R-CHOP Induction Followed by High Dose Therapy with Autologous Stem Cell Transplantation Induces Higher Rates of Molecular Remission In MCL: Results of the MCL Younger Intergroup Trial of the European MCL Network(…
Importance of Achieving Stringent Complete Response After Autologous Stem-Cell Transplantation in Multiple Myeloma (JCO 2013, PMID 24248686) [補足]ここで出てくるCR周辺の判定基準について sCR (stringent CR): CRの基準を満たし、FLC (free light…
Autologous Transplantation as Consolidation for Aggressive Non-Hodgkin's Lymphoma (N Engl J Med 2013;369:1681-1690. DOI: 10.1056/NEJMoa1301077) [背景] IPIでhigh-intermediate riskまたはhigh riskに該当する中悪性度リンパ腫の第1寛解期における…
Long-term progression-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell rescue: a nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group.(Blood 2008;112:2687-269…
Immunochemotherapy and Autologous Stem-Cell Transplantation for Untreated Patients With Mantle-Cell Lymphoma: CALGB 59909 (JCO 2009;27:6101-6108)[目的] マントル細胞リンパ腫(MCL)は予後不良のaggressive B細胞非ホジキンリンパ腫である。著者らは…
