Morbidity and Mortality Differences Between Hematopoietic Cell Transplantation Survivors and Other Cancer Survivors PMID: 27870568, DOI: 10.1200/JCO.2016.68.8457 www.ncbi.nlm.nih.gov 目的 造血幹細胞移植(HCT)を受けた患者と、マッチさせた(HCT…
Addition of Androgens Improves Survival in Elderly Patients With Acute Myeloid Leukemia: A GOELAMS Study J Clin Oncol. 2017;35:387-393 PMID: 28129526, DOI: 10.1200/JCO.2016.67.6213 www.ncbi.nlm.nih.gov 目的 急性骨髄性白血病(AML)の高齢患者…
Autotransplant with and without induction chemotherapy in older multiple myeloma patients: long-term outcome of a randomized trial. Haematologica. 2016;101:1398-1406. www.ncbi.nlm.nih.gov 高齢の多発性骨髄腫に対する自家移植は議論の余地があ…
Chemotherapeutic intensity and survival differences in young patients with diffuse large B-cell lymphoma: a Swedish Lymphoma Registry study. Br J Haematol. 2016, PMID 27790699 www.ncbi.nlm.nih.gov 若年のびまん性大細胞性B細胞リンパ腫(DLBCL)…
Continuing dilemmas in the management of lymphoma during pregnancy: review of a 10-point case-based questionnaire. Int J Clin Oncol. 2016, PMID 27743147 背景 妊娠中のリンパ腫は稀であるため、管理についてのガイドラインは後ろ向き研究とケース…
High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial. Lancet Haematol. 2016;3:e388-397 www.ncbi.nlm.nih.gov 背景 大量メトトレキサー…
Primary Central Nervous System Lymphoma (PCNSL): Analysis of Treatment by Gamma Knife Radiosurgery and Chemotherapy in a Prospective, Observational Study. Cureus. 2016;8:e697. www.ncbi.nlm.nih.gov 背景 中枢神経原発リンパ腫(PCNSL)は脳、中枢…
A Comprehensive Assessment of Toxicities in Patients with CNS Lymphoma Undergoing Autologous Stem Cell Transplantation Using Thiotepa, Busulfan and Cyclophosphamide Conditioning. Biol Blood Marrow Transplant. 2016, PMID 27713090 www.ncbi.n…
Similar incidence of severe acute GVHD and less severe chronic GVHD in PBSCT from unmanipulated, haploidentical donors compared with that from matched sibling donors for patients with haematological malignancies. Br J Haematol. 2016, PMID …
新しい論文ではありませんが、当ブログの検索ワードで「FLIPI2」が多かったので記事にしました。 Follicular lymphoma international prognostic index 2: a new prognostic index for follicular lymphoma developed by the international follicular lymph…
The prognostic value of multiparametric flow cytometry in AL amyloidosis at diagnosis and at the end of first line treatment. Blood. 2016, 27729322 www.ncbi.nlm.nih.gov ALアミロイドーシスにおけるマルチパラメーターフローサイトメトリー(MFC)…
Serum free light chains should be the target of response evaluation in light chain multiple myeloma rather than urines. Blood. 2016, PMID 27729323 www.ncbi.nlm.nih.gov 軽鎖のみを発言している骨髄腫(light chain multiple myeloma; LCMM)のモニ…
Upfront use of plerixafor and granulocyte-colony stimulating factor (GCSF) for stem cell mobilization in patients with multiple myeloma: efficacy and analysis of risk factors associated with poor stem cell collection efficiency. Leuk Lymph…
CNS International Prognostic Index: A Risk Model for CNS Relapse in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP. J Clin Oncol. 2016 Sep 10;34(26):3150-6 PMID: 27382100, DOI: 10.1200/JCO.2015.65.6520 目的 びまん性大細胞…
Diffuse large B-cell lymphoma with testicular involvement: outcome and risk of CNS relapse in the rituximab era. Br J Haematol. 2016, PMID 27739058 www.ncbi.nlm.nih.gov リツキシマブを治療に加えることで、びまん性大細胞型B細胞リンパ腫(DLBCL)…
Overall survival of patients with relapsed multiple myeloma treated with panobinostat or placebo plus bortezomib and dexamethasone (the PANORAMA 1 trial): a randomised, placebo-controlled, phase 3 trial. (Lancet Haematol. 2016, PMID 277517…
Daratumumab, Lenalidomide, and Dexamethasone for Multiple Myeloma. (N Engl J Med. 2016;375:1319-1331) www.ncbi.nlm.nih.gov 背景 daratumumabは、再発・難治骨髄腫患者を対象とした第1、2相試験において、単剤、またはレナリドミドとデキサメタゾンと…
Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma. www.ncbi.nlm.nih.gov 背景 骨髄腫細胞は一様にCD38を発現している。著者らはCD38を標的としたヒトIgG1κ型モノクローナル抗体であるdaratumumabについて、再発骨髄腫または再発後2種類以…
Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma. N Engl J Med. 2016 Aug 25;375(8):754-66. www.ncbi.nlm.nih.gov 背景 ダラツムマブはCD38を標的としたヒトIgGκ型モノクローナル抗体であり、直接的、間接的に抗骨髄腫活性を誘導し、濃…
Hodgkin lymphoma: a negative interim-PET cannot circumvent the need for end-of-treatment-PET evaluation. Br J Haematol., PMID: 27539639 www.ncbi.nlm.nih.gov 著者らは、interim PET (int-PET)が陰性の場合に治療終了時のPET (end-PET)を省略できる…
記事名が長く、分かりづらくて申し訳ないです。。。 Obinutuzumab plus bendamustine versus bendamustine monotherapy in patients with rituximab-refractory indolent non-Hodgkin lymphoma (GADOLIN): a randomised, controlled, open-label, multicentr…
Adapted Treatment Guided by Interim PET-CT Scan in Advanced Hodgkin’s Lymphoma N Engl J Med 2016;374:2419-2429 背景 進行期ホジキンリンパ腫の治療をガイドすることを目的に、化学療法に対する早期の反応性を評価する方法としてのinterim PET-CTを評…
Risk Factors and Outcomes for Patients With Follicular Lymphoma Who Had Histologic Transformation After Response to First-Line Immunochemotherapy in the PRIMA Trial.J Clin Oncol. 2016 Jun 13. pii: JCO657163. [Epub ahead of print], PMID 272…
Randomized Trial of Lenalidomide Alone Versus Lenalidomide Plus Rituximab in Patients With Recurrent Follicular Lymphoma: CALGB 50401 (Alliance) [JCO 2015;33:3635-3640] 目的 レナリドマイドとリツキシマブの併用(LR)は濾胞性リンパ腫(FL)に効果…
Cytomegalovirus Reactivation after Allogeneic Hematopoietic Stem Cell Transplantation is Associated with a Reduced Risk of Relapse in Patients with Acute Myeloid Leukemia Who Survived to Day 100 after Transplantation: The Japan Society for…
Low Serum Vitamin D Levels Are Associated With Inferior Survival in Follicular Lymphoma: A Prospective Evaluation in SWOG and LYSA Studies (JCO 2015;33:1482-1490) 目的 近年、ビタミンD高値がリンパ腫の予後を改善する可能性が報告されている。著…
Risk of venous and arterial thrombotic events in patients diagnosed with superficial vein thrombosis: a nationwide cohort study (Blood 2015;125:229-235) 近年、表在静脈血栓症(superficial vein thrombosis; SVT)は重篤な合併症であるかもしれない…
Secondary monoclonal gammopathy of undetermined significance after allogeneic stem cell transplantation in multiple myeloma (Haematologica 2014;99:1846-1853) 多発性骨髄腫の経過において、初発時と異なるM蛋白のバンド：二次性のMGUS(monoclonal …
Prognostic significance of pleural or pericardial effusion and the implication of optimal treatment in primary mediastinal large B-cell lymphoma: a multicenter retrospective study in Japan (Haematologica 2014;99:1817-1825) 近年、縦隔原発大…
Improved outcome of adult Burkitt lymphoma/leukemia with rituximab and chemotherapy: report of a large prospective multicenter trial (Blood 2014;124:3870-3879) この最大の前向き多施設参加臨床試験は成人のバーキットリンパ腫/白血病を対象として…
